“What We Talk About When We Talk About Anne Frank” (the title story of this compilation) is about the generation(s) of Jewish Americans that grew up after the holocaust. For the most part, they’d lived generally worry-free lives, with some members of the generation eventually moving “back” from the US to Israel.
Speaking of US and Israel, this story does touch on some differences in culture between those in the US and in Israel. While those difference may exist in the details, some things, such as love and family, are universal.
Nathan Eglander spent the first part of the story creating context and building out this little world. Yes, it can get a little specific, but this story focuses on the universal things—things that anyone regardless of race and religion can relate to. While you need to know of Anne Frank and of the holocaust for context, the question asked at the end of the day is quite universal: do you trust your neighbors?